研究活動 RESERCH

研究活動

研究の特色/内容

  1. 地域医療、在宅医療に関する研究
  2. 内科学診断学、治療学に関する研究
  3. 相模原市緑区の健康調査

実践している臨床研究について

  1. 地域医療、在宅医療に関する研究
  2. 相模原市寄附講座「地域総合医療学」に属する医師や学生が、相模原市緑区の医療に ついて調査をしています
  3. 相模原市緑区の住民意識調査を実施して、緑区の医療体制を再構築する試み
  4. 維持透析患者の末梢動脈疾患の合併を早期に発見し早期から治療介入することは透析 患者の予後改善に寄与するか
  5. 大学病院における夜間内科救急診療について
  6. 全身症候を主訴とした外来診療のクリニカルインデイケーターについて

研究業績

原著論文（英文）

  1. Hashimoto A, Tejima S, Tono T, Suzuki M, Tanaka S, Matsui T, Tohma S, Endo H, Hirohata S：Predictors of survival and causes of death in Japanese patients with systemic sclerosis. J Rheumatol. 38:1931-9, 2011.
  2. Nishinari M, Aoyama N, Ogawa Z, Yukino S, Oka S, Yano K, Kurosaki Y, Yano K, Kato S, Takehana H, Izumi T：Clinical state of acute myocardial infarction with increased phosphoglucomutase activity and acute thrombosis. Journal of Analytical Bio-Science 35(2): 157-167, 2012.
  3. Nishinari M, Aoyama N, Ogawa Z, Yukino S, Oka S, Yano K, Kurosaki Y, Takeuchi I, Imaki R, Tojo T, Shimohama T, Takehana H, Izumi T：Phosphoglucomutase activity as a novel biomarker in patients with acute myocardial infarction. Circ J. 76(9):2197-2203, 2012.　
  4. Tejima S, Tono T, Nagai T, Hirohata S：Differential in vitro effects of biological agents on cytokine production of peripheral blood mononuclear cells. Kitasato Medical J. 43:126-32, 2013.
  5. Aoyama N, Imai H, Kurosawa T, Fukuda N, Moriguchi M, Nishinari M, Nishii M, Kono K, Soma K, Izumi T：Therapeutic strategy using extracorporeal life support, including appropriate indication, management, limitation and timing of switch to ventricular assist device in patients with acute myocardial infarction. J Artif Organs. 17(1):33-41, 2014.
  6. Tono T, Aihara S, Hoshiyama T, Arinuma Y, Nagai T, Hirohata S：Effects of TNF inhibitors　on human monocytes. Kitasato Medical J. 44:117-24, 2014.
  7. Matsuzawa R, Aoyama N, Yoshida A：Clinical Characteristics of Patients on Hemodialysis With Peripheral Arterial Disease. Angiology. 66(10):911-917, 2015.
  8. Tono T, Aihara S, Hoshiyama T, Arinuma Y, Nagai T, Hirohata S：Effects of anti-IL-6 receptor antibody on human monocytes. Mod Rheumatol. 25:79-84, 2015.
  9. Hoshiyama T, Matsueda Y, Tono T, Arinuma Y, Nagai T, Hirohata S：Effects of certolizumab pegol on human monocytes. Kitasato Med J. 46:60-6, 2016.
  10. Aoyama N, Nishinari M, Ohtani S, Kanai A, Noda C, Hirata M, Miyamoto A, Watanabe M, Minamino T, Izumi T, Ako J：Clinical features and predictors of patients with critical limb ischemia who responded to autologous mononuclear cell transplantation for therapeutic angiogenesis. Heart Vessels. 32 (9):1099-1108，2017.
  11. Tono T, Aihara S, Hoshiyama T, Arinuma Y, Nagai T, Hirohata S：Effects of CTLA4-Ig on human monocytes. Inflammation Regenerat. 37:24:1-6, 2017.
  12. Harada M, Matsuzawa R, Aoyama N, et al.：Asymptomatic peripheral artery disease and mortality in patients on hemodialysis. Renal Replacement Therapy. 4:17, 2018.
  13. Hoshiyama T, Matsueda Y, Tono T, Arinuma Y, Nagai T, Hirohata S：Differential influences of Fc gamma receptor blocking on the effects of certolizumab pegol and infliximab on human monocytes. Mod Rheumatol. 28:506-512, 2018.
  14. Hoshiyama T, Wada T, Nihonyanagi S, Kameda R, Yamaoka-Tojo M, Fukuda M, Ako J,　Yamaoka K, Takayama Y：Clinical and microbiological features of asymptomatic SARS-CoV-2 infection and mild COVID-19 in seven crewmembers of a cruise ship.
    Internal Medicine. 15; 59(24):3135-3140, 2020.
  15. Horiguchi Y, Uemura K, Aoyama N, et al：Prognosis of hemodialysis patients with progressive aortic stenosis: a prospective cohort study. Ren Replace Ther. 7(1):48-55, 2021.
  16. Komatsu T, Ryosuke Inagaki, Shintaro Azuma, Shunya Mochida, Yosuke Sato, Yoshinori Seto, Shin Nihonyanagi, Takayuki Hoshiyama, Tatsuhiko Wada, Yoko Takayama, Koichiro Atsuda：Evaluation of a carbapenem antimicrobial stewardship program and clinical outcomes in a Japanese hospital. J Infect Chemother. 28(7): 884-889, 2022.
  17. Takayama Y, Komatsu T, Wada T, Nihonyanagi S, Hoshiyama T, Moriya T, Shimamura S, Kajigaya N, Naito M, Takeuchi O, Bando Y, Watanabe M, Iwamura M, Hanaki H：Pre-Vaccination Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Seroprevalence in Workers at Three Japanese Hospitals. J Nippon Med Sch. 89(5):513-519, 2022.
  18. Tono T, Kikuchi H, Sawada T, Takeno M, Nagafuchi H, Kirino Y, Tanaka Y, Yamaoka K, Hirohata S：Clinical Features of Behçet's Disease Patients with Joint Symptoms in Japan: A National Multicenter Study. Mod Rheumatol. 32:1146-1152, 2022.

原著論文（和文）

  1. 田中 住明, 小川 英佑, 東野 俊洋, 廣畑 俊成：肺高血圧症治療薬の併用療法について　膠原病に伴う肺高血圧症に対する併用療法. Therapeutic Research (0289-8020)30巻10号 Page1567-1569, 2009.
  2. 五野由佳理、小田口浩、早崎知幸、鈴木邦彦、及川哲郎、村主明彦、赤星透、花輪壽彦：漢方薬による薬物性肝障害の症例検討、日本東洋医学雑誌、61(6):828-833, 2010.
  3. 西成真琴、青山直善、大谷慎一、金井昭文、加藤伸太朗、渡辺昌文、平田光博、和泉徹：重症虚血肢における自家末梢血単核球細胞移植治療奏功例の臨床像、The Journal of Japanese Society of Limb Salvage and Podiatric Medicine 3(3):121-128, 2011.
  4. 及川哲郎、五野由佳理、福田知顕、堀川朋恵、堀田広満、森裕紀子、川鍋伊晃、石毛達也、小田口浩、若杉安希乃、奥富俊之、花輪壽彦：黄ゴンによる薬物性肝障害が疑われた3例、日本東洋医学雑誌、66(3):212-217, 2015.
  5. 西成田亮、庭野慎一、松浦元、荒川雄紀、小林周平、白川裕基、堀口愛、中村洋範、石末成哉、及川淳、五十嵐巌、岸原淳、佐藤陽、深谷英平、青山直善、阿古潤哉：北里大学病院救急部門における失神診療の現状．心電図 Vol 39, supple.2, S-2-41-47, 2019

症例報告

  1. 青山　直善，東野　俊洋，星山　隆行：繰り返す失神にて紹介受診した高齢者 Adoms-Stokes 症候群の１例．日病総診誌2023；19(2)：124-126．